If I was laid off from my job in mo. Can I file if unemployment at the illinois office or do I have to go to mo.
You're wrong. You would have to file in Illinois.
If you work in MO, then you shouldn't be filing for unemployment at all. Regardless of where you live. But, let's assume that you meant to say that you lost your job in MO or you used to work in MO, the answer is that it doesn't matter what state you used be employed in, you file for unemployment in the state that you reside in. If you have ever looked at your pay stub, you will notice some things on there for IL. Example: I used to live in the county but I had a job in the city. Guess what? I still had to pay city taxes and such because I was employed there.